[Retracted] DNA Binding and Photocleavage Studies of Cobalt(III) Polypyridine Complexes: [Co(en)2PIP]3+, [Co(en)2IP]3+, and [Co(en)2phen-dione]3+

Nagababu, Penumaka; Satyanarayana, S.

doi:https://doi.org/10.1155/2007/54562

Bioinorganic Chemistry and Applications

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Research Article | Open Access

Volume 2007 | Article ID 054562 | https://doi.org/10.1155/2007/54562

[Retracted] DNA Binding and Photocleavage Studies of Cobalt(III) Polypyridine Complexes: [Co(en)₂PIP]³⁺, [Co(en)₂IP]³⁺, and [Co(en)₂phen-dione]³⁺

Penumaka Nagababu¹and S. Satyanarayana¹

Academic Editor: Nick Katsaros

Received18 Oct 2006

Revised25 Jan 2007

Accepted21 Mar 2007

Published24 Jun 2007

Abstract

In this paper, three complexes of type [Co(en)2PIP]3+(PIP=2-phenylimidazo[4,5-f][1,10,] phenanthroline)(1), [Co(en)2IP]3+ (IP=imidazo[4,5-f][1,10,] phenanthroline)(2), and [Co(en)2phen-dione]3+(1,10 phenanthroline 5,6,dione)(3) have been synthesized and characterized by UV/VIS, IR, 1H NMR spectral methods. Absorption spectroscopy, emission spectroscopy, viscosity measurements, and DNA melting techniques have been used for investigating the binding of these two complexes with calf thymus DNA, and photocleavage studies were used for investigating these binding of these complexes with plasmid DNA. The spectroscopic studies together with viscosity measurements and DNA melting studies support that complexes 1 and 2 bind to CT DNA(=calf thymus DNA) by intercalation mode via IP or PIP into the base pairs of DNA, and complex 3 is binding as groove mode. Complex 1 binds more avidly to CT DNA than 2 and 3 which is consistent with the extended planar ring π system of PIP. Noticeably, the two complexes have been found to be efficient photosensitisers for strand scissions in plasmid DNA.

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Copyright © 2007 Penumaka Nagababu and S. Satyanarayana. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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