In Vitro Evaluation of a Stable Monomeric Gold(II) Complex with Hematoporphyrin IX: Cytotoxicity against Tumor and Kidney Cells, Cellular Accumulation, and Induction of Apoptosis
Table 1
IC50 values of Au(II). and cisplatin against a panel of tumor cell lines assessed after
72-hour exposure (MTT-dye reduction assay).
Cell line
Origin/Cell type
IC50(M)
cisplatin
Au(II).
LAMA-84
chronic myeloid leukaemia
65.1
20.3
K-562
chronic myeloid leukaemia
161.2
32.0
SKW-3(a)
T-cell leukaemia
7.6
11.7
DOHH-2
nonHodgkin lymphoma
50.1
35.0
HD-MY-Z
Hodgkinโs lymphoma
43.1
12.2
MGH-U1(b)
urinary bladder cancer
56.4
5.9
MCF-7
breast cancer
166.8
33.4
SAOS-2
osteogenic sarcoma
>200
15.2
Neuro-2a
murine neuroblastoma
>200
>200
(a) KE-37 derivative; (b) Formerly designated as EJ.