Research Article

In Vitro Evaluation of a Stable Monomeric Gold(II) Complex with Hematoporphyrin IX: Cytotoxicity against Tumor and Kidney Cells, Cellular Accumulation, and Induction of Apoptosis

Table 1

IC50 values of Au(II) ๐œ‡ . ๐œ‡ and cisplatin against a panel of tumor cell lines assessed after 72-hour exposure (MTT-dye reduction assay).

Cell lineOrigin/Cell typeIC50(M)cisplatin
Au(II) ๐œ‡ . ๐œ‡

LAMA-84chronic myeloid leukaemia65.120.3
K-562chronic myeloid leukaemia161.232.0
SKW-3(a)T-cell leukaemia7.611.7
DOHH-2nonHodgkin lymphoma50.135.0
HD-MY-ZHodgkinโ€™s lymphoma43.112.2
MGH-U1(b)urinary bladder cancer56.45.9
MCF-7breast cancer166.833.4
SAOS-2osteogenic sarcoma>20015.2
Neuro-2amurine neuroblastoma>200>200

(a) KE-37 derivative;
(b) Formerly designated as EJ.