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Bioinorganic Chemistry and Applications
Volume 2009 (2009), Article ID 542979, 12 pages
Research Article

Synthesis, Characterization, and Biological Studies of Organotin(IV) Derivatives with o- or p-hydroxybenzoic Acids

1Section of Inorganic and Analytical Chemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece
2Department of Chemistry, Qena Faculty of Science, South Valley University, Qena 83523, Egypt
3Faculty of Chemistry, Adam Mickiewicz University, ul. Grunwaldzka 6, 60-780 Poznan, Poland
4Physics of Material Laboratory, Department of Physics, University of Ioannina, 45110 Ioannina, Greece
5Medical Physics Laboratory, Medical School, University of Ioannina, 45110 Ioannina, Greece
6Department of Experimental Physiology, Medical School, University of Ioannina, 45110 Ioannina, Greece
7Department of Chemistry, McGill University, 801 Sherbrooke, Montreal QC, Canada H2A 2K6

Received 6 November 2008; Accepted 14 January 2009

Academic Editor: Lorenzo Pellerito

Copyright © 2009 Mohamed A. Abdellah et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Organotin(IV) complexes with o- or p-hydroxybenzoic acids (o- or p-) of formulae (where = o- and R = Me- (1), -Bu- (2)); (where = o- and R = -Bu- (3), Ph- (4) or = p- and R = -Bu- (5), Ph- (6)) were synthesized by reacting a methanolic solution of di- and triorganotin(IV) compounds with an aqueous solution of the ligand (o- or p-) containing equimolar amounts of potassium hydroxide. The complexes were characterized by elemental analysis, FT-IR, Far-IR, TGA-DTA, FT-Raman, Mössbauer spectroscopy, , , UV/Vis spectroscopy, and Mass spectroscopy. The X-ray crystal structures of complexes 1 and 2 have also been determined. Finally, the influence of these complexes 1–6 upon the catalytic peroxidation of linoleic acid to hydroperoxylinoleic acid by the enzyme lipoxygenase (LOX) was kinetically studied and the results showed that triorganotin(IV) complex 6 has the lowest value. Also complexes 1–6 were studied for their in vitro cytotoxicity against sarcoma cancer cells (mesenchymal tissue) from the Wistar rat, and the results showed that the complexes have high activity against these cell lines with triphenyltin((IV) complex 4 to be the most active one.