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Bioinorganic Chemistry and Applications
Volume 2009, Article ID 906836, 10 pages
Research Article

DNA Oxidative Cleavage Induced by the Novel Peptide Derivatives of 3-(quinoxalin-6-yl)alanine in Combination with Cu(II) or Fe(II) Ions

1Faculty of Chemistry, University of Wrocław, Joliot-Curie 14, 50-383 Wrocław, Poland
2Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawińskiego 5a, 02-106 Warsaw, Poland
3Microbiological Institute, University of Wrocław, Przybyszewskiego 63, 51-148 Wrocław, Poland
4Medical University of Wrocław, Pasteura 4, 50-367 Wrocław, Poland

Received 22 September 2009; Accepted 17 December 2009

Academic Editor: Viktor Brabec

Copyright © 2009 Wojciech Szczepanik et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Figure 1: The CD spectra of the Cu(II) complexed by the studied ligands showing different electronic transitions in each system.

Figure 2: The MCD spectra of the Fe(II) complexes with DPPZa‐Gly and DPQa‐Gly. The DFQa‐Gly ligand does not yield any spectrum with Fe(II) in either CD or MCD spectroscopy.

Figures 3 & 4: The electrophoretic assay analogous to that in Fig. 5 in the manuscript, however with the two remaining ligands used in the reaction mixture.

Figure 5: The assay showing the retarded mobility of the DNA in the samples containing DPPZa-Gly. The possible explanation of this fact might be the intercalation but there is not enough proof.

  1. Supplementary Material