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Bioinorganic Chemistry and Applications
Volume 2010 (2010), Article ID 149149, 11 pages
Research Article

Antineoplastic Activity of New Transition Metal Complexes of 6-Methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone: X-Ray Crystal Structures of [VO2(mpETSC)] and [Pt(mpETSC)Cl]

1Department of Chemistry, McGill University, Montreal, QC, H3A 2K6, Canada
2Chemistry Department, Faculty of Science, Mansoura University, Damietta 34517, Egypt
3Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt
4Department of Medicine, Royal Victoria Hospital, Montreal, QC, H3A 1A1, Canada

Received 14 March 2010; Accepted 14 April 2010

Academic Editor: Spyros Perlepes

Copyright © 2010 Shadia A. Elsayed et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


New complexes of dioxovanadium(V), zinc(II), ruthenium(II), palladium(II), and platinum(II) with 6-methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone (HmpETSC) have been synthesized. The composition of these complexes is discussed on the basis of elemental analyses, IR, Raman, NMR (H1, C13, and P31), and electronic spectral data. The X-ray crystal structures of [VO2(mpETSC)] and [Pt(mpETSC)Cl] are also reported. The HmpETSC and its [Zn(HmpETSC)Cl2] and [Pd(mpETSC)Cl] complexes exhibit antineoplastic activity against colon cancer human cell lines (HCT 116).