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Bioinorganic Chemistry and Applications
Volume 2010 (2010), Article ID 196064, 9 pages
http://dx.doi.org/10.1155/2010/196064
Research Article

The Effect of Stereochemistry on Sodium Ion Complexation in Nucleoside-Metallacarborane Conjugates

1Laboratory of Molecular Virology and Biological Chemistry, Institute for Medical Biology of the Polish Academy of Sciences, Lodowa 106, 93-232 Łódź, Poland
2Faculty of Chemistry, Adam Mickiewicz University, Grunwaldzka 6, 60-780 Poznań, Poland

Received 18 February 2010; Accepted 11 May 2010

Academic Editor: Igor Fritsky

Copyright © 2010 Agnieszka B. Olejniczak et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Conjugates of purine and pyrimidine nucleosides: thymidine and 2 -deoxyguanosine with cobalt-metallacarborane were studied for their sodium ion complexing properties. Formation of stable complexes of 1 : 1 stoichiometry was proved by ESI MS spectroscopy and 2 3 N a NMR. Equilibrium constants and energies of complex formation were calculated. Complexation of alkali-metals by nucleoside-metallacarborane conjugates may affect the physicochemical and biological properties of the conjugates and should be taken into consideration during biological evaluation of these types of modifications.