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Bioinorganic Chemistry and Applications
Volume 2010, Article ID 315056, 11 pages
Review Article

Tetramic and Tetronic Acids as Scaffolds in Bioinorganic and Bioorganic Chemistry

1Laboratory of Organic Chemistry, School of Chemical Engineering, National Technical University of Athens, 15773 Athens, Greece
2Laboratory of Inorganic Chemistry, Department of Chemistry, University of Athens, Panepistimiopolis, 15771 Athens, Greece
3ALAPIS Pharmaceuticals, R & D Centre, Pallini, 15302 Attiki, Greece

Received 28 December 2009; Accepted 23 February 2010

Academic Editor: Spyros Perlepes

Copyright © 2010 G. Athanasellis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Tetramic and tetronic acids are naturally occurring molecules with a variety of biological activities. In this review article, we present the general strategies for the synthesis of these compounds and we reveal the functionalized groups that are responsible for their properties. We also set out their coordinating modes with up-to-date bibliographical references.