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Bioinorganic Chemistry and Applications
Volume 2010, Article ID 563875, 7 pages
Research Article

Synthesis, Solution, and Structural Characterization of Tetrahydrofuranyl-2,2-Bisphosphonic Acid Disodium Salt

1Department of Chemistry, University of Cyprus, 1678 Nicosia, Cyprus
2Agricultural Production and Biotechnology and Food Science, Cyprus University of Technology, 3036 Lemesos, Cyprus

Received 2 January 2010; Accepted 26 February 2010

Academic Editor: Spyros Perlepes

Copyright © 2010 Elena Maltezou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Bisphosphonates are biologically relevant therapeutics for bone disorders and cancer. Reaction of -chlorobutyric acid, phosphorus acid, and phosphorus trichloride without the use of solvent gave the tetrahydrofuranyl-2,2-bisphosphonate sodium salt ( ). The was isolated, characterized in solution by , , and NMR spectroscopy and in solid state by single X-Ray crystallography. The crystal structure showed that the forms in the crystal infinite two-dimensional sheets stacked one parallel to the other. A comparison of the chelating properties of with similar hydroxyl bisphosphonate ligands shows that the strength of the Na–O(furanyl/hydroxyl) bond is directly related to the total charge of the ligand anion.