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Bioinorganic Chemistry and Applications
Volume 2010, Article ID 854514, 9 pages
http://dx.doi.org/10.1155/2010/854514
Research Article

Novel Organotin(IV)-Schiff Base Complexes: Synthesis, Characterization, Antimicrobial Activity, and DNA Interaction Studies

1Department of Chemistry, University of Mysore, Manasagangotri, Mysore 570 006, Karnataka, India
2Department of Biotechnology, University of Mysore, Manasagangotri, Mysore 570 006, Karnataka, India

Received 21 July 2010; Revised 10 November 2010; Accepted 2 December 2010

Academic Editor: Viktor Brabec

Copyright © 2010 K. Shiva Prasad et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Four organotin(IV) complexes with 2-(2-hydroxybenzylideneamino)isoindoline-1,3-dione (L1), and 4-(4-hydroxy-3-methoxybenzylideneamino-N-(pyrimidin-2-yl)benzenesulfonamide (L2) were synthesized and well characterized by analytical and spectral studies. The synthesized compounds were tested for antimicrobial activity by disc diffusion method. The DNA binding of the complexes 1 and 3 with CT-DNA has been performed with absorption spectroscopy, which showed that both the complexes are avid binders of CT-DNA. Also the nuclease activity of complexes 1 and 3 with plasmid DNA (pUC19) was studied using agarose gel electrophoresis. The complex 1 can act as effective DNA cleaving agent when compared to complex 3 resulting in the nicked form of DNA under physiological conditions. The gel was run both in the absence and presence of the oxidizing agent.