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Bioinorganic Chemistry and Applications
Volume 2011 (2011), Article ID 206316, 8 pages
http://dx.doi.org/10.1155/2011/206316
Research Article

Impact of Vanadium Complexes Treatment on the Oxidative Stress Factors in Wistar Rats Plasma

1Department of Bioorganic Chemistry, Medical College, Faculty of Pharmacy, Jagiellonian University, 9 Medyczna Street, 30-688 Krakow, Poland
2Department of Food Chemistry and Nutrition, Medical College, Faculty of Pharmacy, Jagiellonian University, 9 Medyczna Street, 30-688 Krakow, Poland
3Medical College, Faculty of Pharmacy, Jagiellonian University, 9 Medyczna Street, 30-688 Krakow, Poland
4Faculty of Chemistry, Jagiellonian University, 9 Ingardena Street, Krakow, Poland
5Department of Pharmacodynamics, Medical College, Faculty of Pharmacy, Jagiellonian University, 9 Medyczna Street, 30-688 Krakow, Poland

Received 13 June 2011; Accepted 12 July 2011

Academic Editor: Concepción López

Copyright © 2011 R. Francik et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The aim of this study was to investigate the clinical efficacy of vanadium complexes on triglycerides (TG), total cholesterol (Chol), uric acid (UA), urea (U), and antioxidant parameters: nonenzymatic (FRAP—ferric reducing ability of plasma, and reduced glutathione—GSH) and enzymatic (glutathione peroxidase—GPx, catalase—CAT, and GPx/CAT ratio) activity in the plasma of healthy male Wistar rats. Three vanadium complexes: [VO(bpy)2]SO4·2H2O, [VO(4, Me2bpy)2]SO4·2H2O, and Na[VO(O2)2(bpy)]·8H2O are administered by gavage during 5 weeks in two different diets such as control (C) and high fatty (F) diets. Changes of biochemical and antioxidants parameters are measured in plasma. All three vanadium complexes statistically decrease the body mass growth in comparison to the control and fatty diet. In plasma GSH was statistically increased in all vanadium complexes-treated rats from control and fatty group in comparison to only control group. Calculated GPX/CAT ratio was the highest in the control group in comparison to others.