Selectivity of Inhibition of N-Succinyl-l,l-Diaminopimelic Acid Desuccinylase in Bacteria: The product of dapE-gene Is Not the Target of l-Captopril Antimicrobial Activity
Figure 1
DapE independent inhibition of E. coli by L-captopril. (a) The strain has constitutively expressed endogenous dapE gene, and the medium was also supplemented with mDAP; (b) the strain has constitutively expressed endogenous dapE gene but the medium was not supplemented with mDAP; (c) the strain has overexpressed plasmid encoded DapE (in addition to the constitutively expressed endogenous DapE) and the medium was also supplemented with mDAP; (d) the strain has overexpressed plasmid encoded DapE (in addition to the constitutively expressed endogenous DapE) but the medium was not supplemented with mDAP.
