Selectivity of Inhibition of N-Succinyl-l,l-Diaminopimelic Acid Desuccinylase in Bacteria: The product of dapE-gene Is Not the Target of l-Captopril Antimicrobial Activity

Table 2

Inhibition of E. coli growth by L-captopril.

Strain with endogenous DapE	TN5960 (Plasmid without dapE gene)		TN5962 (Plasmid with dapE gene)
Supplemented with mDAP	Yes	No	Yes	No
	Radius of zone of inhibition by L-captopril
25 mg/mL	0.2 cm	0.2 cm	0.2 cm	0.2 cm
50 mg/mL	0.2 cm	0.2 cm	0.2 cm	0.2 cm
20 mg	1.2 cm	1.2 cm	1.2 cm	1.2 cm