The Rieske Iron-Sulfur Protein: Import and Assembly into the Cytochrome 𝑏𝑐₁ Complex of Yeast Mitochondria

Figure 2

Schematic model depicting the last steps of assembly of the yeast cytochrome 𝑏𝑐₁ complex. The 500 kDa 𝑏𝑐₁ subcomplex, which also includes the chaperone protein Bcs1p, sequentially binds ISP and, finally, Qcr10p, in a process which leads to the formation of the homodimeric 𝑏𝑐₁ complex. In the final step, supercomplexes assembly involves the sequential addition of cytochrome 𝑐 oxidase complex (complex IV) to homodimeric cytochrome 𝑏𝑐₁ complex (complex III).