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Bioinorganic Chemistry and Applications
Volume 2011 (2011), Article ID 898726, 5 pages
http://dx.doi.org/10.1155/2011/898726
Research Article

Antioxidant Activities of Plumbagin and Its Cu (II) Complex

1Department of Chemistry and Biology, Yulin Normal College, Yulin 537000, China
2The Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources of Ministry of Education, School of Chemistry, Chemical Engineering, Guangxi Normal University, Guilin 541004, China

Received 31 July 2011; Accepted 19 August 2011

Academic Editor: Zhe-Sheng Chen

Copyright © 2011 Mingxiong Tan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Plumbagin and its Cu (II) complex [Cu (plumbagin)2]·H2O have been synthesized, and their antioxidant activities towards the inhibitory effect on DPPH free radical, reducing power, total antioxidant capacity, and inhibition on lipid peroxidation were investigated. Plumbagin and its Cu (II) complex were found to exhibit scavenging activities on DPPH radical with the inhibitory rate of 41% and 24%, respectively. The reducing power of plumbagin was outstanding at the concentrations of 1.0, 1.5, and 2.0 mg/mL, compared to Cu (II) complex and synthetic antioxidant 2,6-di-ter-butyl-4-methylphenol (BHT); the highest level reached 1.333 for plumbagin and 0.581 for Cu (II) complex. Also, the inhibition on lipid peroxidation of plumbagin was higher than that of Cu (II) complex and BHT, 46.4% for plumbagin and 24.5% for Cu (II) complex. The results give a strong impact for designing anticancer drugs, combined with their potential cytotoxic and antioxidant activities, which can be targeted selectively against cancer cells and increase their therapeutic index and additional advantages over other anticancer drugs.