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Bioinorganic Chemistry and Applications
Volume 2012 (2012), Article ID 123953, 8 pages
Research Article

Electrospun Nanostructured Fibers of Collagen-Biomimetic Apatite on Titanium Alloy

1Dipartimento di Chimica “G. Ciamician,” Alma Mater Studiorum Università di Bologna, Via Selmi 2, 40126 Bologna, Italy
2Dipartimento di Scienze Mediche, Università del Piemonte Orientale, Via Solaroli 17, 28100 Novara, Italy
3Dipartimento di Scienze e Tecnologie Chimiche, Università Politecnica delle Marche, Via Brecce Bianche, 60131 Ancona, Italy

Received 27 July 2011; Accepted 17 October 2011

Academic Editor: Giovanni Natile

Copyright © 2012 Michele Iafisco et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Titanium and its alloys are currently the mainly used materials to manufacture orthopaedic implants due to their excellent mechanical properties and corrosion resistance. Although these materials are bioinert, the improvement of biological properties (e.g., bone implant contact) can be obtained by the application of a material that mimics the bone extracellular matrix. To this aim, this work describes a new method to produce nanostructured collagen-apatite composites on titanium alloy substrate, by combining electrospinning and biomimetic mineralization. The characterization results showed that the obtained mineralized scaffolds have morphological, structural, and chemical compositional features similar to natural bone extracellular matrix. Finally, the topographic distribution of the chemical composition in the mineralized matrix evaluated by Fourier Transform Infrared microspectroscopy demonstrated that the apatite nanocrystals cover the collagen fibers assembled by the electrospinning.