Pharmacokinetic Study of Di-Phenyl-Di-(2,4-Difluobenzohydroxamato)Tin(IV): Novel Metal-Based Complex with Promising Antitumor Potential

Table 3

Stability results of DPDFT at different conditions in rat plasma (𝑛=6).

Storage period and storage condition	Nominal concentration (μg·mL^−1)	Observed concentration (μg·mL^−1) ± SD	Accuracy (%)	RSD (%)
Concentration of fresh preparation	0.8	0.85±0.07	6.25	8.2
	4	3.91±0.12	−2.25	3.1
	20	21.06±1.33	5.30	6.3
Three freeze and thaw cycles	0.8	0.76±0.05	−5.00	6.6
	4	3.79±0.13	−5.25	3.5
	20	18.97±1.17	−5.15	6.2
Stability for 72 h at 4°C	0.8	0.87±0.04	8.75	4.6
	4	3.70±0.16	−7.50	4.3
	20	21.14±1.27	5.70	6.0
Stability for 72 h at −20°C	0.8	0.74±0.05	−7.50	6.8
	4	4.22±0.12	5.50	2.9
	20	19.13±1.53	−4.35	7.9
Stability for 72 h at room temperature	0.8	0.78±0.05	−2.50	6.4
	4	3.87±0.19	−3.25	4.9
	20	19.46±1.19	−2.75	6.1
Autosampler stability for 24 h at 10°C	0.8	0.83±0.04	3.75	4.8
	4	3.83±0.18	−4.25	4.7
	20	19.19±1.08	−4.05	5.6

Notes: accuracy (%) = [(Cobs − Cnom)/Cnom] × 100, RSD = [standard deviation (SD)/Cobs] × 100.