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Bioinorganic Chemistry and Applications
Volume 2013 (2013), Article ID 360142, 9 pages
Research Article

Stabilization of Submicron Calcium Oxalate Suspension by Chondroitin Sulfate C May Be an Efficient Protection from Stone Formation

1College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China
2Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou 510632, China

Received 5 July 2013; Revised 26 October 2013; Accepted 10 November 2013

Academic Editor: Imre Sovago

Copyright © 2013 Jun-Jun Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The influences of chondroitin sulfate C (C6S) on size, aggregation, sedimentation, and Zeta potential of sub-micron calcium oxalate monohydrate (COM) and calcium oxalate dihydrate (COD) crystallites with mean sizes of about 330 nm were investigated using an X-ray diffractometer, nanoparticle size Zeta potential analyzer, ultraviolet spectrophotometer, and scanning electron microscope, after which the results were compared with those of micron-grade crystals. C6S inhibited the conversion of COD to COM and the aggregation of COM and COD crystallitesis; it also decreased their sedimentation rate, thus increasing their stability in aqueous solution. The smaller the size of the COD crystallites, the easier they can be converted to COM. The stability of sub-micron COD was worse than that of micron-grade crystals. C6S can inhibit the formation of calcium oxalate stones.