Synthesis and In Vitro Antitumor Activity of Two Mixed-Ligand Oxovanadium(IV) Complexes of Schiff Base and Phenanthroline

Table 2

Comparison of IC₅₀ values obtained from the MTT assay on BEL-7402, HUH-7, and HepG2 hepatoma cell lines after treated for 24 h, 48 h, and 72 h using the complexes 1 and 2.

Cell line	Subject	IC50 values obtained from the MTT assay (μM)
		24 h	48 h	72 h
BEL-7402	1	294.30 ± 95.74	30.80 ± 13.05	0.51 ± 0.21
	2	166.32 ± 20.48	17.02 ± 3.69	0.90 ± 0.13
HUH-7	1	69.91 ± 11.08	2.87 ± 0.23	3.12 ± 0.39
	2	79.16 ± 25.18	1.98 ± 0.72	0.28 ± 0.09
HepG2	1	12.21 ± 1.09	1.81 ± 0.38	5.02 ± 0.14
	2	4.32 ± 0.98	1.33 ± 0.37	1.71 ± 0.10

Data are the mean ± SD of at least three independent experiments. ^∗𝑃 < 0.05; ^∗∗𝑃 < 0.01. ^∗𝑃<0.05 versus the control, the difference was significant. ^∗∗𝑃<0.01 versus the control, the difference was markedly significant.