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Bioinorganic Chemistry and Applications
Volume 2013, Article ID 565032, 12 pages
Research Article

Synthesis, Characterization, and Interaction with Biomolecules of Platinum(II) Complexes with Shikimic Acid-Based Ligands

State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Chemical Engineering of Guangxi Normal University, Guilin 541004, China

Received 1 October 2012; Accepted 3 January 2013

Academic Editor: Concepción López

Copyright © 2013 Yan Peng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Figure S1: Capillary electrophoresis plot of four platinum(II) complexes. The electrophoresis experimental conditions: running buffer pH 7.0, 5 mmol/L PBS buffer (containing 10% methanol); capillary column 30 cm×50 µm i.d.; detected wavelength λ = 214 nm; applied voltage 20 kV; input sample time 8 s; concentration 1×10-3 mol/L. Figure S2: LC-MS spectra of for platinum(II) complexes. Analytical separations were carried out on a reversed phase column (XB-C18, 3μm, 2.1×150mm,) with detection at 300 nm. Mobile phase A: water, B: methanol, the flow rate was 0.3 mL min-1, The gradient (Solvent B) was as follows: 0% to 2% within 3 min, 2% to 5% from 3 to 5 min, reset to 10% from 5 to 30 min. Figure S3: Electrophoretic mobility of pUC19 plasmId DNA. DNA was equilibrated with increasing concentrations of Lc for 3 h at 37. Lane 1: DNA, Lane 2~6: DNA + L3 (10, 50, 100, 200, 300µM).

  1. Supplementary Figures