Inhibitory Effect of Curcumin-Cu(II) and Curcumin-Zn(II) Complexes on Amyloid-Beta Peptide Fibrillation

<div class="floats-full-page floats-full-page-figure"><h2>Figure 7</h2><div class="floats-full-page-caption"><table>AFM images showing oligomeric assemblies of 10 <svg height="12.175" id="M44" style="vertical-align:-2.29482pt" version="1.1" viewbox="0 0 9.5625 12.175" width="9.5625" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> treated with 30 <svg height="12.175" id="M46" style="vertical-align:-2.29482pt" version="1.1" viewbox="0 0 9.5625 12.175" width="9.5625" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,7.675)"><path d="M538 96q-38 -45 -84 -76.5t-71 -31.5q-44 0 -15 117q12 49 18 89h-2q-99 -128 -163 -178q-36 -28 -70 -28q-26 0 -44 38h-2q-16 -69 -16 -129q0 -43 11 -75.5t24 -42.5l1 -6q-7 -12 -24.5 -23t-37.5 -11q-40 0 -40 76q0 52 35 202l94 407l78 24l5 -5q-32 -122 -72 -310&#10;q-7 -33 0 -55t25 -22q36 0 105.5 75t107.5 145l32 146l75 26h10q-50 -197 -78 -347q-7 -38 6 -38q7 0 31 17t47 39z" id="x1D707"></path></g>
</svg>M Curcumin-Cu(II) complex after incubation for (a) 3 hrs and (b) 16 days at room temperature. No fibril formation was observed after 16 days of incubation.</table></div><div class="floats-full-page-content"><table class="table-group" width="800px"><tr class="fig-image" id="a"><td><img alt="325873.fig.007a" src="https://static-02.hindawi.com/articles/bca/volume-2014/325873/figures/325873.fig.007a.jpg" /></td></tr><tr class="fig-caption"><td align="center"><table><tr><td><b>(a) </b></td></tr></table></td></tr><tr class="fig-image" id="b"><td><img alt="325873.fig.007b" src="https://static-02.hindawi.com/articles/bca/volume-2014/325873/figures/325873.fig.007b.jpg" /></td></tr><tr class="fig-caption"><td align="center"><table><tr><td><b>(b) </b></td></tr></table></td></tr></table></div></div>

Figure 7 | Inhibitory Effect of Curcumin-Cu(II) and Curcumin-Zn(II) Complexes on Amyloid-Beta Peptide Fibrillation

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Figure 7: Inhibitory Effect of Curcumin-Cu(II) and Curcumin-Zn(II) Complexes on Amyloid-Beta Peptide Fibrillation

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Figure 7

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Bioinorganic Chemistry and Applications | Hindawi

Bioinorganic Chemistry and Applications publishes research in all aspects of bioinorganic chemistry, including bioorganometallic chemistry and applied bioinorganic chemistry, and applications in fields such as medicine and immunology.