Protonation Equilibria of Biologically Active Ligands in Mixed Aqueous Organic Solvents

Table 1

The autoprotolysis constants () obtained for various water-solvent mixtures.

Medium
Water	13.78^a, 13.69^b, 13.77^c
20% ethanol—80% water	14.03^d
30% ethanol—70% water	14.17^a, 14.16^b
40% ethanol—60% water	14.30^d
50% ethanol—50% water	14.40^a, 14.28^b
60% ethanol—40% water	14.48^d
70% ethanol—30% water	14.67^a, 14.59^b
12.5% dioxane—87.5% water	14.17^e
20% dioxane—80% water	14.31^f, 14.22^b
25% dioxane—75% water	14.37^e
37.5% dioxane—62.5% water	14.50
40% dioxane—60% water	14.89^f, 14.86^b
50% dioxane—50% water	15.44^e
60% dioxane—40% water	15.54^f, 15.62^b
62.5% dioxane—37.5% water	15.70^e
70% dioxane—30% water	15.75^e
50% DMSO—50% water	15.48^g

^aData taken from reference [38], ^bdata taken from reference [37], ^cdata taken from reference [39], ^ddata taken from reference [40], ^edata taken from reference [41], ^fdata taken from reference [42], and ^gdata taken from reference [43].