Synthesis and Biological Evaluation of New Hydrazone Derivatives of Quinoline and Their Cu(II) and Zn(II) Complexes against <i>Mycobacterium tuberculosis</i>

<table class="table-group" id="tab7"><tr><td><table class="table"><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr class="thead"><td align="left"> </td><td align="center">Complexes</td><td align="center">Molar conductance Λ<svg height="6.20645pt" id="M31" style="vertical-align:-0.2063999pt" version="1.1" viewbox="-0.0498162 -6.00005 10.6039 6.20645" width="10.6039pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M781 91L765 118C733 86 702 70 693 70C686 70 685 77 692 106L738 297C772 439 736 451 712 451S675 445 647 431C605 410 526 356 452 257H450L459 294C491 426 459 451 429 451C403 451 386 445 361 431C312 404 239 343 170 253H168L188 333C208 411 205 451 175 451C148 451 85 417 24 346L39 318C57 338 100 374 112 374C120 374 122 372 115 339C91 226 62 112 28 -6L37 -12C59 -4 87 3 114 6C125 68 142 127 154 168C184 227 316 383 372 383C397 383 396 366 381 289C362 192 338 92 312 -6L317 -12C339 -5 367 3 396 6L434 170C468 234 598 383 650 383C668 383 676 369 664 319L609 90C593 23 600 -12 629 -12C654 -12 722 23 781 91Z" id="g50-110"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="805" vert-adv-y="805"></glyph.data></g></svg> (Ω<sup>−1</sup> mol<sup>−1</sup> cm<sup>2</sup>)</td></tr><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr><td align="left" rowspan="5">Zn complexes</td><td align="center">3a</td><td align="center">3.6</td></tr><tr><td align="center">3b</td><td align="center">4.9</td></tr><tr><td align="center">3c</td><td align="center">3.2</td></tr><tr><td align="center">3d</td><td align="center">2.9</td></tr><tr><td align="center">3e</td><td align="center">5.3</td></tr><tr><td align="center" colspan="3"><hr/></td></tr><tr><td align="left" rowspan="5">Cu complexes</td><td align="center">3f</td><td align="center">7.30</td></tr><tr><td align="center">3g</td><td align="center">4.83</td></tr><tr><td align="center">3h</td><td align="center">6.42</td></tr><tr><td align="center">3i</td><td align="center">4.74</td></tr><tr><td align="center">3j</td><td align="center">3.32</td></tr><tr class="table-tr"><td colspan="3"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Molar conductance (Λ<svg height="6.20645pt" id="M30" style="vertical-align:-0.2063999pt" version="1.1" viewbox="-0.0498162 -6.00005 10.6039 6.20645" width="10.6039pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M781 91L765 118C733 86 702 70 693 70C686 70 685 77 692 106L738 297C772 439 736 451 712 451S675 445 647 431C605 410 526 356 452 257H450L459 294C491 426 459 451 429 451C403 451 386 445 361 431C312 404 239 343 170 253H168L188 333C208 411 205 451 175 451C148 451 85 417 24 346L39 318C57 338 100 374 112 374C120 374 122 372 115 339C91 226 62 112 28 -6L37 -12C59 -4 87 3 114 6C125 68 142 127 154 168C184 227 316 383 372 383C397 383 396 366 381 289C362 192 338 92 312 -6L317 -12C339 -5 367 3 396 6L434 170C468 234 598 383 650 383C668 383 676 369 664 319L609 90C593 23 600 -12 629 -12C654 -12 722 23 781 91Z" id="g50-110"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="805" vert-adv-y="805"></glyph.data></g></svg>) of Cu(II) and Zn(II) complexes.

Bioinorganic Chemistry and Applications

tab7

Table 7

Table 7: Synthesis and Biological Evaluation of New Hydrazone Derivatives of Quinoline and Their Cu(II) and Zn(II) Complexes against <i>Mycobacterium tuberculosis</i> 

Table 7 | Synthesis and Biological Evaluation of New Hydrazone Derivatives of Quinoline and Their Cu(II) and Zn(II) Complexes against Mycobacterium tuberculosis 