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Bioinorganic Chemistry and Applications
Volume 2015, Article ID 923087, 7 pages
Research Article

Synthesis and Characterization with Antineoplastic, Biochemical, Cytotoxic, and Antimicrobial Studies of Schiff Base Cu(II) Ion Complexes

Inorganic Research Laboratory, Department of Chemistry, University of Rajshahi, Rajshahi 6205, Bangladesh

Received 3 April 2015; Revised 26 June 2015; Accepted 12 July 2015

Academic Editor: Guillermo Mendoza-Diaz

Copyright © 2015 M. M. Haque et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Copper(II) complexes containing two Schiff base ligands derived from 2-hydroxybenzaldehyde with 2-aminophenol and 3-aminophenol have been synthesized and characterized by means of analytical, magnetic, and spectroscopic methods. Bacteria, fungus, Entamoeba histolytica, and antineoplastic activities of the synthesized complexes have been determined by monitoring the parameters cell growth inhibition, survival time of tumour mice, time-body relation, causing of intraperitoneal cells and macrophages, alkaline phosphatase activity, hematological effect, and biopsy of tumour.