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Bioinorganic Chemistry and Applications
Volume 2017, Article ID 4101735, 12 pages
Review Article

Hazardous Effects of Titanium Dioxide Nanoparticles in Ecosystem

1Department of Chemistry, Quaid-i-Azam University, Islamabad, Pakistan
2Department of Chemistry, Tsinghua University, Beijing 100084, China
3Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Science Park, Guangzhou 510530, China
4Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan

Correspondence should be addressed to Syed Niaz Ali Shah; moc.liamg@tsylanailazain and Zahir Shah;

Received 23 December 2016; Accepted 8 February 2017; Published 8 March 2017

Academic Editor: Muataz A. Atieh

Copyright © 2017 Syed Niaz Ali Shah et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Although nanoparticles (NPs) have made incredible progress in the field of nanotechnology and biomedical research and their applications are demanded throughout industrial world particularly over the past decades, little is known about the fate of nanoparticles in ecosystem. Concerning the biosafety of nanotechnology, nanotoxicity is going to be the second most priority of nanotechnology that needs to be properly addressed. This review covers the chemical as well as the biological concerns about nanoparticles particularly titanium dioxide (TiO2) NPs and emphasizes the toxicological profile of TiO2 at the molecular level in both in vitro and in vivo systems. In addition, the challenges and future prospects of nanotoxicology are discussed that may provide better understanding and new insights into ongoing and future research in this field.