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Bioinorganic Chemistry and Applications
Volume 2017, Article ID 4276919, 6 pages
Research Article

Synthesis and Cytotoxic Evaluation of Steroidal Copper (Cu (II)) Complexes

1Key Laboratory of Beibu Gulf Environment Change and Resources Utilization, College of Chemistry and Material Science, Guangxi Teachers Education University, Nanning 530001, China
2Guangxi Colleges and University Key Laboratory of Beibu Gulf Oil and Natural Gas Resource Effective Utilization, Qizhou University, Qizhou, China

Correspondence should be addressed to Jianguo Cui; moc.621@4591gjiuc

Received 21 November 2016; Accepted 24 April 2017; Published 18 October 2017

Academic Editor: Giovanni Natile

Copyright © 2017 Yanmin Huang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Using estrone and pregnenolone as starting materials, some steroidal copper complexes were synthesized by the condensation of steroidal ketones with thiosemicarbazide or diazanyl pyridine and then complexation of steroidal thiosemicarbazones or steroidal diazanyl pyridines with Cu (II). The complexes were characterized by IR, NMR, and HRMS. The synthesized compounds were screened for their cytotoxicity against HeLa, Bel-7404, and 293T cell lines in vitro. The results show that all steroidal copper (II) complexes display obvious antiproliferative activity against the tested cancer cells. The IC50 values of complexes 5 and 12 against Bel-7404 (human liver carcinoma) are 5.0 and 7.0 μM.