Synthesis and Cytotoxic Evaluation of Steroidal Copper (Cu (II)) Complexes

Table 1

Cytotoxicity of steroidal thiosemicarbazone and its Cu-complexes in vitro (IC₅₀: µM)

Compounds	Bel-7404	HeLa	293T
1	19	34	ND
2	>200	42	>200
5	5.0	11	27
6	13	7.7	11
7	9.5	6.8	15.3
8	14.1	10.6	9.1
11	14	ND	14
12	7.0	ND	9.0
Cisplatin	23.2	10.1	10.3

Cytotoxicity as IC₅₀ for each cell line is the concentration of compound which reduced by 50% the optical density of treated cells with respect to untreated cells using the MTT assay. Data represent the mean values of the three independent determinations. ND: not determined.