A Review on Platelet Activating Factor Inhibitors: Could a New Class of Potent Metal-Based Anti-Inflammatory Drugs Induce Anticancer Properties?

Table 1

IC₅₀ (μM, final concentration) of various PAF inhibitors that induces 50% inhibition against PAF aggregation in washed rabbit platelets (WRPs). IC₅₀ (μL) values are expressed in microliters of initial volume of oil that induces 50% inhibition against 1 × 10⁻¹¹ M PAF final concentration in the aggregometer cuvette.

PAF inhibitor	IC50	Reference
Ginkgolides
BN 52021	3.6	[13]
BN 52020	9.7	[13]
BN 52022	38	[13]
Alpha-bulnesene	0.024	[17]
Cedrol	13	[29]
Paricalcitol	0.3	[100]
Di-hydroxy-chimyl-alcohol (pine pollen)	4.5	[27]
Olive oil	6.5 μL	[74]
Sunflower	21 μL	[88]
Sesame oil	150 μL	[88]