Review Article
A Review on Platelet Activating Factor Inhibitors: Could a New Class of Potent Metal-Based Anti-Inflammatory Drugs Induce Anticancer Properties?
Table 3
IC50 data (μM) final concentration in the aggregometer cuvette for metal complexes bearing PNP ligands as PAF inhibitors.
| | Number | PNP complexes | ΙC50 |
| | Cu-1 | Cu(OPPh2)(OPPh2)N-O,O}2 | ~1.0 | | Zn-1 | Zn(OPPh2)(OPPh2)N-O,O}2 | 0.54 | | Zn-2 | Zn(SPPh2)(SPPh2)N-S,S}2 | 0.36 | | Zn-3 | Ζn(OPPh2)(SePPh2)N-O,Se}2 | | | Ga-1 | Ga(OPPh2)(OPPh2)N-O,O}3 | | | Ni-1 | Ni(Ph2P)2N-S-CHMePh-P,P}Cl2 | ~16 | | Ni-2 | Ni(Ph2P)2N-S-CHMePh-P,P}Βr2 | ~3.0 | | Ni-3 | Ni(OPPh2)(SePPh2)N-O,Se}2 | | | Co-1 | Co(OPPh2)(SePPh2)N-O,Se}2 | |
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