Pharmacological and Toxicological Threshold of Bisammonium Tetrakis 4-(<i>N</i>,<i>N</i>-Dimethylamino)pyridinium Decavanadate in a Rat Model of Metabolic Syndrome and Insulin Resistance

<div>Histological features in the liver and visceral white adipose tissue after V10-DMAP administration. (a)–(d) Liver biopsies with H&amp;E staining. The central vein was taken as a reference. (e)–(h) Visceral adipose tissue biopsies with H&amp;E staining. Magnification images were acquired with a 40x objective. The blue arrow indicates inflammation by infiltrating leukocytes. The black arrow indicates hepatic cell necrosis. The red arrow indicates balloon cell or Mallory–Denk bodies. The asterisk indicates triglyceride storage area in adipocytes. The green arrow indicates blood vessels.</div>

Bioinorganic Chemistry and Applications

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Figure 4

Figure 4: Pharmacological and Toxicological Threshold of Bisammonium Tetrakis 4-(<i>N</i>,<i>N</i>-Dimethylamino)pyridinium Decavanadate in a Rat Model of Metabolic Syndrome and Insulin Resistance 

Figure 4 | Pharmacological and Toxicological Threshold of Bisammonium Tetrakis 4-(N,N-Dimethylamino)pyridinium Decavanadate in a Rat Model of Metabolic Syndrome and Insulin Resistance 