Structure-Based Drug Design for Cytochrome P450 Family 1 Inhibitors

Figure 5

2′,3,4-trimethoxy-trans-stilbene docked to the CYP1A2 (a) and CYP1B1 (b) binding sites. Amino acid residues surrounding the active sites are visualized with Phe226 and Phe231 in black colour. The heme is represented as a stick model in pink. The solid blue lines represent π-π stacking interactions.

(a)

(b)