Effect of Ultrafine Powderization and Solid Dispersion Formation via Hot-Melt Extrusion on Antioxidant, Anti-Inflammatory, and the Human Kv1.3 Channel Inhibitory Activities of Angelica gigas Nakai
Anti-inflammatory activity of water extracts of different processed AGN. (a) Effect of water extracts of different processed AGN on the cell viability. (b) Inhibitory effect of water extracts of different processed AGN on LPS-induced NO production in RAW 264.7 macrophages. (c) Inhibitory effect of WES on LPS-induced PGE2 production in RAW 264.7 macrophages. (d) Effect of WES on iNOS, COX-2, TNF-α, IL-1β, and IL-6 expressions in LPS-treated RAW264.7 cells. (e) Suppression of LPS-induced ROS in RAW 264.7 cells in the presence of WES: (A) control (no treatment); (B) 1 μg/mL LPS treatment; (C) 1 μg/mL LPS treatment after 100 μg/mL of WES addition; (D) 1 μg/mL LPS treatment after 300 μg/mL of WES addition; (E) 1 μg/mL LPS treatment after 500 μg/mL of WES addition. (f) Histogram showing intracellular ROS in RAW 264.7 macrophage cells. Each value is expressed as the mean ± SD (n = 3). Values in the same column are significantly different by Duncan’s multiple range test ().
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