Ru(II) Complexes Bearing O, O-Chelated Ligands Induced Apoptosis in A549 Cells through the Mitochondrial Apoptotic Pathway

Table 1

Cytotoxic effects of ruthenium (II) complexes on human cancer and normal cell lines^a.

Complexes	IC50 (μM)
	A549	HeLa	MCF-7	HepG2	BEAS-2B	SI
Ru(dip)2Cl2	138.4 ± 6.7	115.6 ± 6.8	134.9 ± 7.9	108.5 ± 5.4	—	—
Ru(dmp)2Cl2	>200	>200	>200	169.3 ± 6.2	—	—
SA	>200	>200	>200	>200	—	—
Ru-1	11.3 ± 1.1^b	20.1 ± 1.3^b	29.5 ± 2.2^b	15.4 ± 1.0	54.3 ± 3.4^b	4.9
Ru-2	30.1 ± 1.2^b	32.5 ± 2.4^b	45.7 ± 3.7^b	26.4 ± 2.1	48.1 ± 3.7^b	1.6
Cisplatin	27.2 ± 1.4	18.3 ± 1.2	16.2 ± 2.0	30.2 ± 2.0	21.4 ± 1.5	0.8

^aCells were treated with various concentrations of complexes for 48 h. SI (selectivity index) = IC₅₀ (BEAS-2B)/IC₅₀ (A549).^b < 0.01 represents significant differences compared with BEAS-2B.