Antibacterial Activity of 2-Picolyl-polypyridyl-Based Ruthenium (II/III) Complexes on Non-Drug-Resistant and Drug-Resistant Bacteria

Table 6

Zones of inhibition of all compounds.

Microbe	Li[Ru(Cl)4(DPA) (2) (mm)	[Ru2(2BUT)(DMF)2(DPA)](BH4)4] (3) (mm)	[Ru2(2BUT)(Cl)6] (4) (mm)	2BUT (1) (mm)	DPA (mm)
S. aureus	9	8	8	8	9
MRSA	0	8	0	0	7
K. pneumoniae	7	7	7	7	8
MDR K. pneumoniae	0	0	0	0	0

The disc diffusion assay was used to the ligands and complexes for their activity towards the three bacterial organisms S. aureus, K. pneumoniae, MRSA, and MDR K. pneumoniae. This was done after their MIC values were assayed to assess the extent to which the compounds inhibit the growth of the bacteria. Just as in the MIC assay, all the compounds indicated activity towards all non-drug-resistant bacteria while [Ru₂(2BUT)(DMF)₂(DPA)](BH₄)₄], [Ru₂(2BUT)(Cl)₆], 2BUT, and DPA had activity towards MRSA. No compounds showed activity on MDR K. pneumoniae.