Synthesis, DNA-Binding, Anticancer Evaluation, and Molecular Docking Studies of Bishomoleptic and Trisheteroleptic Ru-Diimine Complexes Bearing 2-(2-Pyridyl)-quinoxaline

Table 7

In vitro activity of 1, 2, and cis-platin (expressed as IC₅₀ (μM) against MCF-7 cells).

Complexes	MCF-7	HEK-293	References
1	10.5 ± 0.9	n.a
2	6.2 ± 1.2	n.a
Cis-platin	5.19 ± 0.8	6.53 ± 1.1
[Ru(bip)2Cl2]	134.9 ± 7.9		[71]
[Ru(bmp)2Cl2]	>200		[71]
[RuCl3(dmso) (bpy)]	691		[57]
[RuCl3(dmso) (phen)]	679		[57]
cis-[Ru(bpy)2Cl2]	189.2		[72]
cis-[Ru(phen)2Cl2]	>200		[72]
[Cu(pq) (NO3)]NO3	17.4 ± 1.1		[59]
[Cu(pq)2(NO3)]NO3·6H2O	4.92±		[59]

The cytotoxicity study is performed on amorphous material. The IC50 values are the average of three separate experiments_. n.a., not active (IC₅₀ > 100 μM);