Research Article
Synthesis, Structure, and Biologic Activity of Some Copper, Nickel, Cobalt, and Zinc Complexes with 2-Formylpyridine N4-Allylthiosemicarbazone
Table 3
Antiproliferative activities of some synthesized compounds on human leukemia HL‐60 cell line at three concentrations.
| | Compound | Inhibition of cell proliferation, (%) | IC50, μM | | 10 μM | 1 μM | 0.1 μM |
| | HL | 100.3 ± 2.2 | 99.6 ± 0.4 | 1.8 ± 0.1 | 0.30 ± 0.02 | | HLa | 6.1 ± 0.3 | 1.5 ± 0.5 | 0.9 ± 0.2 | — | | HLb | 10.1 ± 0.5 | 9.4 ± 0.6 | 2.3 ± 0.4 | — | | [Zn(H2O) (L)Cl] (1) | 102.4 ± 1.1 | 101.1 ± 3.7 | 3.0 ± 0.4 | 0.20 ± 0.03 | | [Cu(L)Cl] (2) | 99.4 ± 0.6 | 99.2 ± 0.2 | 40.2 ± 2.8 | 0.10 ± 0.06 | | [Cu(L)Br] (3) | 100.0 ± 0.1 | 100.0 ± 0.3 | 24.5 ± 1.9 | 0.10 ± 0.04 | | [Cu2L2(CH3COO)2]·4H2O (4) | 100.0 ± 0.2 | 99.8 ± 0.2 | 32.0 ± 2.3 | 0.10 ± 0.02 | | [Ni(HL)2]Cl2·H2O (5) | 108.5 ± 0.5 | 94.9 ± 0.7 | 54.5 ± 1.1 | 0.09 ± 0.01 | | [Co(L)2]Cl (6) | 24.1 ± 0.6 | 6.9 ± 1.7 | 4.1 ± 0.3 | >10 | | Doxorubicin | 95.0 ± 0.6 | 92.9 ± 0.7 | 16.5 ± 1.8 | 0.2 ± 0.1 |
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