A NMR-Based Metabolomic Approach to Investigate the Antitumor Effects of the Novel [Pt(<i>η</i><sup>1</sup>-C<sub>2</sub>H<sub>4</sub>OMe)(DMSO)(phen)]<sup>+</sup> (phen = 1,10-Phenanthroline) Compound on Neuroblastoma Cancer Cells

<div>Schematic biochemical representation of the main metabolic pathways altered at six hours after Pt-EtOMeSOphen treatment. Box plots show the trend of highly significant altered metabolites (<svg height="10.2124pt" id="M11" style="vertical-align:-3.42943pt" version="1.1" viewbox="-0.0498162 -6.78297 7.83752 10.2124" width="7.83752pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M570 304C570 398 525 448 414 448C385 448 343 445 312 434L329 511L321 518C297 504 262 482 244 460L233 411C195 397 159 381 128 358L135 332C160 347 189 360 224 373L111 -147C97 -210 84 -218 17 -231L13 -257L254 -247L259 -218L233 -216C183 -212 177 -202 189 -142L218 -1C238 -10 266 -12 283 -12C351 3 429 48 483 105C543 168 570 242 570 304ZM482 289C482 161 380 33 304 33C278 33 248 51 233 69L303 396C326 400 352 403 369 403C428 403 482 380 482 289Z"></path></g></svg>value &lt;0.01). Black: control cells; blue: Pt-EtOMeSOphen. Glu: glutamate, Gly: glycine, GSH: glutathione, <i>α</i>-KG: alpha-ketoglutarate, Ala: alanine, Pyr: pyruvate, Ser: serine, Ace: acetate, LPA: lysophosphatidic acid, DAG: diacylglycerol, TAG: triacylglycerol, PTC: phosphatidylcholines, GPC: glycerophosphocholine, Cho: choline, PC: phosphocholine, CDP-Cho: cytidine diphosphocholine.</div>

Bioinorganic Chemistry and Applications

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Figure 8

Figure 8: A NMR-Based Metabolomic Approach to Investigate the Antitumor Effects of the Novel [Pt(<i>η</i><sup>1</sup>-C<sub>2</sub>H<sub>4</sub>OMe)(DMSO)(phen)]<sup>+</sup> (phen = 1,10-Phenanthroline) Compound on Neuroblastoma Cancer Cells 

Figure 8 | A NMR-Based Metabolomic Approach to Investigate the Antitumor Effects of the Novel [Pt(η1-C2H4OMe)(DMSO)(phen)]+ (phen = 1,10-Phenanthroline) Compound on Neuroblastoma Cancer Cells 