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Bone Marrow Research
Volume 2011 (2011), Article ID 353878, 8 pages
Review Article

Paracrine Molecules of Mesenchymal Stem Cells for Hematopoietic Stem Cell Niche

Life Science Division, Graduate School at Shenzhen, Tsinghua University , Shenzhen L406A, China

Received 31 May 2011; Revised 26 July 2011; Accepted 26 July 2011

Academic Editor: Joseph H. Antin

Copyright © 2011 Tian Li and Yaojiong Wu. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs) are both adult stem cells residing in the bone marrow. MSCs interact with HSCs, they stimulate and enhance the proliferation of HSCs by secreting regulatory molecules and cytokines, providing a specialized microenvironment for controlling the process of hematopoiesis. In this paper we discuss how MSCs contribute to HSC niche, maintain the stemness and proliferation of HSCs, and support HSC transplantation.