Table of Contents Author Guidelines Submit a Manuscript
Bone Marrow Research
Volume 2011, Article ID 385124, 6 pages
http://dx.doi.org/10.1155/2011/385124
Clinical Study

One-Year Safety Analysis of the COMPARE-AMI Trial: Comparison of Intracoronary Injection of CD133+ Bone Marrow Stem Cells to Placebo in Patients after Acute Myocardial Infarction and Left Ventricular Dysfunction

1Division de Cardiologie, Département de Médecine, Centre Hospitalier de l’Université de Montréal (CHUM), 3840, Rue Saint Urbain, Montréal, Québec, Canada H2W 1T8
2Axe Cardio-Métabolique, Centre de Recherche du CHUM (CRCHUM), Montréal, Québec, Canada H2W 1T7
3Département d'Hématologie, Hôpital Maisonneuve-Rosemont (HMR), Montréal, Québec, Canada H1T 2M4
4Faculté de Médicine, Université de Montréal, Montréal, Québec, Canada H3C 3J7
5Division de Chirurgie Cardiaque, Département de Chirurgie, Centre Hospitalier de l’Université de Montréal (CHUM), Montréal, Québec, Canada H2W 1T8

Received 22 August 2010; Accepted 12 December 2010

Academic Editor: Mark R. Litzow

Copyright © 2011 Samer Mansour et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. A. Jackson, S. M. Majka, H. Wang et al., “Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells,” Journal of Clinical Investigation, vol. 107, no. 11, pp. 1395–1402, 2001. View at Google Scholar · View at Scopus
  2. F. Timmermans, J. de Sutter, and T. C. Gillebert, “Stem cells for the heart, are we there yet?” Cardiology, vol. 100, no. 4, pp. 176–185, 2003. View at Publisher · View at Google Scholar · View at Scopus
  3. A. Rosenzweig, “Cardiac cell therapy—mixed results from mixed cells,” The New England Journal of Medicine, vol. 355, no. 12, pp. 1274–1277, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Hristov, N. Heussen, A. Schober, and C. Weber, “Intracoronary infusion of autologous bone marrow cells and left ventricular function after acute myocardial infarction: a meta-analysis,” Journal of Cellular and Molecular Medicine, vol. 10, no. 3, pp. 727–733, 2006. View at Publisher · View at Google Scholar
  5. M. J. Lipinski, G. G. L. Biondi-Zoccai, A. Abbate et al., “Impact of intracoronary cell therapy on left ventricular function in the setting of acute myocardial infarction. A collaborative systematic review and meta-analysis of controlled clinical trials,” Journal of the American College of Cardiology, vol. 50, no. 18, pp. 1761–1767, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. E. Martin-Rendon, S. J. Brunskill, C. J. Hyde, S. J. Stanworth, A. Mathur, and S. M. Watt, “Autologous bone marrow stem cells to treat acute myocardial infarction: a systematic review,” European Heart Journal, vol. 29, no. 15, pp. 1807–1818, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Abdel-Latif, R. Bolli, I. M. Tleyjeh et al., “Adult bone marrow-derived cells for cardiac repair: a systematic review and meta-analysis,” Archives of Internal Medicine, vol. 167, no. 10, pp. 989–997, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Bhatia, “AC133 expression in human stem cells,” Leukemia, vol. 15, no. 11, pp. 1685–1688, 2001. View at Google Scholar · View at Scopus
  9. E. A. de Wynter, D. Buck, C. Hart et al., “CD34+AC133+ cells isolated from cord blood are highly enriched in long-term culture-initiating cells, NOD/SCID-repopulating cells and dendritic cell progenitors,” Stem Cells, vol. 16, no. 6, pp. 387–396, 1998. View at Google Scholar · View at Scopus
  10. S. Kuçi, J. T. Wessels, H. J. Bühring et al., “Identification of a novel class of human adherent CD34 stem cells that give rise to SCID-repopulating cells,” Blood, vol. 101, no. 3, pp. 869–876, 2003. View at Publisher · View at Google Scholar · View at Scopus
  11. N. Quirici, D. Soligo, L. Caneva, F. Servida, P. Bossolasco, and G. L. Deliliers, “Differentiation and expansion of endothelial cells from human bone marrow CD133+ cells,” British Journal of Haematology, vol. 115, no. 1, pp. 186–194, 2001. View at Publisher · View at Google Scholar · View at Scopus
  12. J. Bartunek, M. Vanderheyden, B. Vandekerckhove et al., “Intracoronary injection of CD133 positive enriched bone marrow progenitor cells promotes cardiac recovery after recent myocardial infarction: feasibility and safety,” Circulation, vol. 112, no. 9, pp. I178–I183, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. S. Mansour, M. Vanderheyden, B. de Bruyne et al., “Intracoronary delivery of hematopoietic bone marrow stem cells and luminal loss of the infarct-related artery in patients with recent myocardial infarction,” Journal of the American College of Cardiology, vol. 47, no. 8, pp. 1727–1730, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Mansour, D. C. Roy, V. Bouchard et al., “COMPARE-AMI trial: comparison of intracoronary injection of CD133+ bone marrow stem cells to placebo in patients after acute myocardial infarction and left ventricular dysfunction: study rationale and design,” Journal of Cardiovascular Translational Research, vol. 3, no. 2, pp. 153–159, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. S. Mansour, D. C. Roy, B. Lemieux, C. Ouellet, L. M. Stevens, and N. Noiseux, “Stem cell therapy for the broken heart: mini-organ transplantation,” Transplantation Proceedings, vol. 41, no. 8, pp. 3353–3357, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. B. E. Strauer, M. Brehm, T. Zeus et al., “Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans,” Circulation, vol. 106, no. 15, pp. 1913–1918, 2002. View at Publisher · View at Google Scholar · View at Scopus
  17. M. Vanderheyden, S. Vercauteren, S. Mansour et al., “Time-dependent effects on coronary remodeling and epicardial conductance after intracoronary injection of enriched hematopoietic bone marrow stem cells in patients with previous myocardial infarction,” Cell Transplantation, vol. 16, no. 9, pp. 919–925, 2007. View at Publisher · View at Google Scholar
  18. M. Peichev, A. J. Naiyer, D. Pereira et al., “Expression of VEGFR-2 and AC133 by circulating human CD34+ cells identifies a population of functional endothelial precursors,” Blood, vol. 95, no. 3, pp. 952–958, 2000. View at Google Scholar · View at Scopus