Review Article
T-Cell Costimulatory Molecules in Acute-Graft-Versus Host Disease: Therapeutic Implications
Table 1
T-cell costimulatory/inhibitory molecules and their ligands.
| | Molecules | Cell expression | Ligand | Cell expression |
| | Stimulatory | | | | | CD28 | T-cells | CD80 (B7-1) | APCs | | CD86 (B7-2) | APCs | | CD40 | APCs | CD40L (CD154) | T-cells (CD4+) | | OX40 (CD134) | T-cells | OX40L | APCs | | 4-1BB (CD137) | T, NK cells | 4-1BBL | APCs | | ICOS | T-cells | ICOSL (B7h) | APCs | | LIGHT | T, NK cells | HVEM | T-cells, APCs | | CD30 | T, NK, B-cells | CD30L (CD153) | T-cells (CD4+) |
| | Inhibitory | | | | | CTLA-4 (CD152) | T-cells | CD 80, CD86 | APCs | | PD-1 | T-cells | PDL1 (B7H1) | DCs, T-cells | | PDL2 (B7DC) | Monocytes |
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APCs: antigen presenting cells.
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