Differential Expression of Matrix Metalloproteinase-2 Expression in Disseminated Tumor Cells and Micrometastasis in Bone Marrow of Patients with Nonmetastatic and Metastatic Prostate Cancer: Theoretical Considerations and Clinical Implications—An Immunocytochemical Study

Table 3

Demographic variables according to Gleason score in men with metastastic disease.

	Gleason 4	Gleason 5 + 6	Gleason 7	Gleason 8 + 9	𝑃 = (statistical test)
No. of patients (𝑛)	1	13	11	5
Mean age ± SD (years)	75.1 ± 7.7	74.2 ± 8.7	75 ± 7.2	74.2 ± 6.5	NS (ANOVA)
Median serum PSA (IQR) ng/mL	26	29 (19.0–150)	31 (22–150.0)	30 (19–150)	NS (Kruksal-Wallis)
Median stage at diagnosis	3	3	3	3	NS (Kruksal-Wallis)
Median time from diagnosis (IQR) (years)	8	8 (5–11)	7 (6–9)	7 (4–9)	NS (Kruksal-Wallis)

IQR: inter-quartile range, CPC: circulating prostate cell, DTC: disseminated tumor cell mM: micrometastasis, and NS: not significant.