Table 4: Frequency of MMP-2 expression in CPCs, DTCs, and mM in patients with nonmetastatic disease.

No. of patientsGleason 4Gleason 5 + 6Gleason 7Gleason 8 + 9 = (statistical test, log regression)

Total 100% ( )15.1% (28)57.3% (106)16.8% (31)10.8% (20)
CPC positive
62.7% ( )
46.4% (13)63.2% (67)64.5% (20)80.0% (16)NS
MMP-2100% (13)100% (67)100% (20)100% (16)NS
DTC positive
62.5% ( )
35.7% (10)65.1% (69)67.7% (21)75.0% (15)
MMP-2100% (10)100% (69)100% (21)100% (15)NS
mM positive
71.4% ( )
32.1% (9)77.4% (82)77.4% (22)85% (17)
MMP-20%a,b,c14.6%a,d (11)20.8%b (5)41.1%c,d (7)a-a < 0.002
b-b < 0.002
c-c < 0.002
d-d < 0.002
Trend chi squared

CPC: circulating prostate cell, DTC: disseminated tumor cell, mM: micrometastasis, and NS: not significant.