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Bone Marrow Research
Volume 2012 (2012), Article ID 270425, 16 pages
Review Article

Hematopoietic Stem Cell Development, Niches, and Signaling Pathways

1Stem Cell Therapy and Transplantation Research Group, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand
2School of Microbiology, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand

Received 9 March 2012; Revised 30 May 2012; Accepted 13 June 2012

Academic Editor: Amanda C. LaRue

Copyright © 2012 Kamonnaree Chotinantakul and Wilairat Leeanansaksiri. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Hematopoietic stem cells (HSCs) play a key role in hematopoietic system that functions mainly in homeostasis and immune response. HSCs transplantation has been applied for the treatment of several diseases. However, HSCs persist in the small quantity within the body, mostly in the quiescent state. Understanding the basic knowledge of HSCs is useful for stem cell biology research and therapeutic medicine development. Thus, this paper emphasizes on HSC origin, source, development, the niche, and signaling pathways which support HSC maintenance and balance between self-renewal and proliferation which will be useful for the advancement of HSC expansion and transplantation in the future.