Role of Killer Immunoglobulin-Like Receptor and Ligand Matching in Donor Selection

Table 1

Characteristics of studies analyzing KIRs or KIR ligands.

Reference	𝑛	Stem cell source	T-cell depletion	Donor type	HLA match	Diagnose
Ruggeri et al. 2002 [3]	92	PB	All	Related	Haploidentical	Various
Bishara et al. 2004 [6]	62	PB	Not all	Related	Haploidentical	Various
Symons et al. 2010 [7]	86	BM	None	Related	Haploidentical	Various
Weisdorf et al. 2012 [8]	24	PB	All	Related	Haploidentical	Myeloid
Cook et al. 2004 [9]	220	?	?	Related	HLA match	Lymphoid, myeloid
Hsu et al. 2005 [10]	178	BM	All	Sibling	HLA match	Various
Dalva et al. 2006 [11]	84	PB/BM	None	Sibling	HLA match	Various
McQueen et al. 2007 [5]	202	PB (89%)/BM	None	Sibling	HLA match	Various
Kim et al. 2007 [12]	53	BM/PB	None	Sibling	HLA match	Myeloid
Giebel et al. 2009 [13]	100	PB/BM	All	Sibling/unrelated	HLA match (81%)	Various
Stringaris et al. 2010 [14]	246	PB/BM	All	Sibling	HLA match	Myeloid
Davies et al. 2002 [15]	175	BM	34%	Unrelated	HLA mismatch	Various
Giebel et al. 2003 [16]	130	BM (96%)	81%	Unrelated	HLA match (47%)	Various
Bornhäuser et al. 2004 [17]	118	BM/PB	All	Unrelated	HLA match (46%)	Myeloid
Schaffer et al. 2004 [18]	190	BM/PB	All	Unrelated	HLA match (49%)	Various
Beelen et al. 2005 [19]	374	BM/PB	None	Unrelated (60%)	HLA match (63%)	CML (63 %)
De Santis et al.; 2005 [20]	104	BM/PB	14% (BM)	Unrelated	HLA mismatch	Various
Kröger et al. 2005 [21]	73	PB (63%)/BM	All	Unrelated	HLA match (86%)	Myeloma
Farag et al. 2006 [22]	1571	BM	None	Unrelated	HLA match (64%)	Various
Miller et al. 2007 [23]	1770	PB/BM	None	Unrelated	HLA match	Various
Yabe et al. 2008 [24]	1489	BM	All	Unrelated	HLA match	Various
Cooley 2009 [25]	448	?	None	Unrelated	HLA match (47%)	Myeloid
Cooley et al. 2010 [26]	1086	?	None	Unrelated	HLA match (50%)	Myeloid, lymphoid
Gagne et al. 2009 [4]	264	BM	None	Unrelated	HLA match (62 %)	Various
Venstrom et al. 2010 [27]	1087	BM (97%)	19%	Unrelated	HLA match (62%)	Myeloid, lymphoid
Brunstein et al. 2009 [28]	257	CB	32%	Unrelated	HLA mismatch (92%)	Various
Willemze et al. 2009 [29]	218	CB	81%	Unrelated	HLA mismatch	Various

BM: bone marrow, PB: peripheral blood, CB: cord blood, and CML: chronic myeloid leukemia.