Influence of Bisphosphonate Treatment on Medullary Macrophages and Osteoclasts: An Experimental Study

Figure 1

Experimental Design. Female Wistar rats were used, divided into three groups: Sham, OPD, and ALN. Each one of the groups was divided into three subgroups and the columns of circles indicate these subsets into which the animals in each group were divided. The rows show weekly administration of vehicle (light gray) or 0.3 mg/kg of the corresponding bisphosphonate olpadronate or alendronate (dark gray). The star indicates the time of administration of the single dose of BrdU, that is, days 7, 28, or 34 of the experiment. All animals were euthanized on day 35 of the experiment.