Review Article

Unrelated Hematopoietic Stem Cell Donor Matching Probability and Search Algorithm

Table 1

Parameters that contribute to define a low probability estimate.

HLA, ethnicity, nb donorsExamples and comments

≤3 donors in BMDW
Non-European ancestry
Rare(1) allele at any locusA*02:17, B*44:05, DRB1*11:03
Rare B-C associationB*18:01-C*02:02, B*51:01-C*16:02
Rare DRB1-DQB1 associationDRB1*15:01-DQB1*06:03, DRB1*0701-DQB1*03:02
B*15:01, B*18:01, B*27:05, B*51:01-positive haplotypesHigher risk of C MM
B*35:02/35:03/35:08-positive haplotypesHigher risk of B*35 allele MM

(1)<5% of the alleles included a given serotype.