Research Article

Adenoviral Delivery of the VEGF and BMP-6 Genes to Rat Mesenchymal Stem Cells Potentiates Osteogenesis

Figure 3

Osteogenesis induced by rMSCs. (a) Reconstructions from axial microCT slices of specimens retrieved from rats injected with Matrigel + cells that were infected with adenovirus (Ad-VEGF+BMP-6). The less porous 3D structure at 4 weeks (right panel) denotes an increase in bone volume as compared to the bone volume at 3 weeks (left panel). (b) Bone volume of the implants retrieved from the rats from 3 groups of subcutaneous (SQ) injections. The bars represent the standard deviations of the means. (*) trace amounts of tissue estimated with no standard deviation. (#) statistical significance between 3 and 4 weeks.