Bone Marrow Vascular Niche: Home for Hematopoietic Stem Cells

Table 1

Molecules	Function	References
FGF-4	Supports the adhesion of megakaryocytes to BMECs	[34, 65]
SDF-1	Induces the transendothelial migration and plays a key role in HSCs differentiation	[58, 59]
VCAM-1	Induces the expression of adhesion molecules	[34, 65]
G-CSF	Causes HSC mobilization	[66]
Tie2	Mediates HSCs to adhesion to osteoblasts, regulating the quiescence in osteoblastic niche	[14]
SCF	A key niche component that maintains HSCs	[71]
E-selectin	Enhances HSC quiescence and self-renewal potential and promotes HSC proliferation	[37]
gp130	Makes significant contribution to hematopoiesis	[73]
PTN	Induces HSC regeneration	[70]