Research Article
Very Long Term Stability of Mixed Chimerism after Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Hematologic Malignancies
Table 1
Distribution of chimerism status based on main transplant features.
| | | FC | MNC-MC | Gran-MC | Total | value | | ( = 89) | ( = 36) | ( = 30) | ( = 155) |
| | Gender | | | | | | | Female (F) | 29 (0.19) | 16 (0.1) | 17 (0.11) | 62 (0.4) | 0.055 | | Male (M) | 60 (0.39) | 20 (0.13) | 13 (0.08) | 93 (0.6) | | Disease | | | | | | | ALL | 16 (0.1) | 6 (0.04) | 3 (0.02) | 25 (0.16) | 0.739 | | AML | 27 (0.17) | 14 (0.09) | 12 (0.08) | 53 (0.34) | | CLL | 3 (0.02) | 0 | 0 | 3 (0.02) | | CML | 17 (0.11) | 8 (0.05) | 7 (0.04) | 32 (0.21) | | Lymphoma | 10 (0.07) | 5 (0.03) | 1 (0.01) | 16 (0.1) | | MDS | 8 (0.05) | 2 (0.01) | 2 (0.01) | 12 (0.08) | | MPN | 2 (0.01) | 0 | 1 (0.01) | 3 (0.02) | | Myeloma | 6 (0.04) | 1 (0.01) | 4 (0.03) | 11 (0.08) | | Conditioning | | | | | | | Standard | 77 (0.5) | 33 (0.21) | 25 (0.16) | 135 (0.87) | 0.585 | | Reduced | 12 (0.08) | 3 (0.02) | 5 (0.03) | 20 (0.13) | | Donor type | | | | | | | Identical sibling | 62 (0.4) | 29 (0.19) | 22 (0.14) | 113 (0.73) | 0.263 | | Unrelated | 21 (0.14) | 7 (0.04) | 8 (0.05) | 36 (0.23) | | Mismatched related | 6 (0.04) | 0 | 0 | 6 (0.04) | | Donor/recipient sex match | | | | | | | F → F | 17 (0.11) | 10 (0.07) | 2 (0.01) | 29 (0.19) | 0.001 | | F → M | 29 (0.19) | 5 (0.03) | 6 (0.04) | 40 (0.26) | | M → F | 12 (0.08) | 6 (0.04) | 15 (0.1) | 33 (0.21) | | M → M | 31 (0.2) | 15 (0.1) | 7 (0.04) | 53 (0.34) | |
T-cell depletion | | | | | | | None | 19 (0.12) | 1 (0.01) | 0 | 20 (0.13) | <0.001 | | T-cell depletion without add-back | 48 (0.31) | 16 (0.1) | 12 (0.08) | 76 (0.49) | | T-cell depletion with add-back | 22 (0.14) | 19 (0.12) | 18 (0.12) | 59 (0.38) | | Stem cells source | | | | | | | Bone marrow | 26 (0.17) | 15 (0.1) | 15 (0.1) | 56 (0.36) | 0.09 | | Peripheral blood | 63 (0.41) | 21 (0.14) | 15 (0.1) | 99 (0.64) | | aGvHD | | | | | | | Grades 0-1 | 60 (0.39) | 31 (0.2) | 25 (0.16) | 116 (0.75) | 0.045 | | Grades 2–4 | 29 (0.19) | 5 (0.03) | 5 (0.03) | 39 (0.25) | | cGvHD | | | | | | | None | 52 (0.34) | 32 (0.21) | 24 (0.16) | 108 (0.7) | 0.009 | | Limited | 21 (0.14) | 3 (0.02) | 3 (0.02) | 27 (0.17) | | Extensive | 16 (0.1) | 1 (0.01) | 3 (0.02) | 20 (0.13) | | DLI | | | | | | | 0 | 68 (0.44) | 29 (0.19) | 20 (0.13) | 117 (0.76) | 0.406 | | ≥1 | 21 (0.14) | 7 (0.04) | 10 (0.07) | 38 (0.24) |
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