BET Inhibition Suppresses S100A8 and S100A9 Expression in Acute Myeloid Leukemia Cells and Synergises with Daunorubicin in Causing Cell Death

Figure 4

Effect of JQ1 on S100A8 and S100A9 protein expression in the OCI-AML-3 cell line. Cells were treated with 0.5μM for 48 hr; then extracts were subject to Western blotting (a) or immunolabeling for S100A8 and S100A9 (b). Counts of highly S100A8 positive cells are shown in (c) (mean ± SEM, n=3). Immunolabeling for S100A8/S100A8 heterodimer is shown in panel (d).

(a)

(b)

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(d)