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Journal of Biomedicine and Biotechnology
Volume 1, Issue 1, Pages 11-17
http://dx.doi.org/10.1155/S1110724301000055
Review article

Trypanosoma Cruzi-Induced Host Immune System Dysfunction: A Rationale for Parasite Immunosuppressive Factor(s) Encoding Gene Targeting

1CJF INSERM n° 96-04, Centre IRD de Montpellier, 911 Av. Agropolis, BP 5945, Montpellier cédex 1 34032, France
2Department of Biochemistry, Faculty of Pharmacy, University of Porto, Portugal
3Laboratory of Clinical Investigations, Vozandes Community Services, Hospital Vozandes, Villalengua 267 y 10 de Agosto, Quito Casilla 17-17-691, Ecuador

Copyright © 2001 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [31 citations]

The following is the list of published articles that have cited the current article.

  • Margarida Borges, Anabela Cordeiro Da Silva, Denis Sereno, and Ali Ouaissi, “Peptide-based analysis of the amino acid sequence important to the immunoregulatory function of Trypanosoma cruzi Tc52 virulence factor,” Immunology, vol. 109, no. 1, pp. 147–155, 2003. View at Publisher · View at Google Scholar
  • Edwin Garzón, Margarida Coutinho Borges, Anabela Cordeiro-da-Silva, Valeria Nacife, Maria de Nazareth Meirelles, Eliane Guilvard, Marie France Bosseno, Angel Gustavo Guevara, Simone Frédérique Brenière, and Ali Ouaissi, “Trypanosoma cruzi carrying a targeted deletion of a Tc52 protein-encoding allele elicits attenuated Chagas' disease in mice,” Immunology Letters, vol. 89, no. 1, pp. 67–80, 2003. View at Publisher · View at Google Scholar
  • Rj Viotti, C Vigliano, S Laucella, B Lococo, M Petti, G Bertocchi, Br Vera, and H Armenti, “Value of echocardiography for diagnosis and prognosis of chronic Chagas disease cardiomyopathy without heart failure,” Heart, vol. 90, no. 6, pp. 655–660, 2004. View at Publisher · View at Google Scholar
  • Ali Ouaissi, Mehdi Ouaissi, Joana Tavares, and Anabela Cordeiro-Da-Silva, “Host cell phenotypic variability induced by trypanosomatid-parasite- released immunomodulatory factors: Physiopathological implications,” Journal of Biomedicine and Biotechnology, vol. 2004, no. 3, pp. 167–174, 2004. View at Publisher · View at Google Scholar
  • E. Garzon, F. Genna, M. F. Bosseno, J. Simony-La Fontaine, M. Radal, D. Sereno, F. Mathieu-Daude, A. Ouaissi, and S. F. BreniÈRe, “Differential infectivity and immunopathology in murine experimental infections by two natural clones belonging to the Trypanosoma cruzi I lineage,” Parasitology, vol. 131, no. 1, pp. 109–119, 2005. View at Publisher · View at Google Scholar
  • M. Borges, A. Cordeiro-da-Silva, B. Vergnes, D. Sereno, and A. Ouaissi, “Conversion of Trypanosoma cruzi Tc52 released factor to a protein inducing apoptosis,” Tissue and Cell, vol. 37, no. 6, pp. 469–478, 2005. View at Publisher · View at Google Scholar
  • Rodolfo Viotti, and Carlos Vigliano, “Etiological treatment of chronic Chagas disease: neglected ‘evidence’ by evidence-based medicine,” Expert Review of Anti-infective Therapy, vol. 5, no. 4, pp. 717–726, 2007. View at Publisher · View at Google Scholar
  • Rodolfo Viotti, and Carlos Vigliano, “Etiological treatment of chronic Chagas disease: neglected 'evidence' by evidence-based medicine,” Expert Review Of Anti-Infective Therapy, vol. 5, no. 4, pp. 717–726, 2007. View at Publisher · View at Google Scholar
  • Françoise Mathieu-Daudé, Marie-France Bosseno, Edwin Garzon, Joël Lelièvre, Denis Sereno, Ali Ouaissi, and Simone Frédérique Brenière, “Sequence diversity and differential expression of Tc52 immuno-regulatory protein in Trypanosoma cruzi: potential implications in the biological variability of strains,” Parasitology Research, vol. 101, no. 5, pp. 1355–1363, 2007. View at Publisher · View at Google Scholar
  • G.K. Abdalla, G.E.L. Faria, K.T. Silva, E.C.C. Castro, M.A. Reis, and M.A. Michelin, “Trypanosoma cruzi: The role of PGE2 in immune response during the acute phase of experimental infection,” Experimental Parasitology, vol. 118, no. 4, pp. 514–521, 2008. View at Publisher · View at Google Scholar
  • Pablo M. Beldomenico, Sandra Telfer, Stephanie Gebert, Lukasz Lukomski, Malcolm Bennett, and Michael Begon, “The vicious circle and infection intensity: The case of Trypanosoma microti in field vole populations,” Epidemics, vol. 1, no. 3, pp. 162–167, 2009. View at Publisher · View at Google Scholar
  • Rodolfo Viotti, Carlos A. Vigliano, María G. Álvarez, Bruno E. Lococo, Marcos A. Petti, Graciela L. Bertocchi, and Alejandro H. Armenti, “El impacto de las condiciones socioeconómicas en la evolución de la enfermedad de Chagas crónica,” Revista Española de Cardiología, vol. 62, no. 11, pp. 1224–1232, 2009. View at Publisher · View at Google Scholar
  • Rodolfo Viotti, Carlos A. Vigliano, María G. Álvarez, Bruno E. Lococo, Marcos A. Petti, Graciela L. Bertocchi, and Alejandro H. Armenti, “The Impact of Socioeconomic Conditions on Chronic Chagas Disease Progression,” Revista Española de Cardiología (English Edition), vol. 62, no. 11, pp. 1224–1232, 2009. View at Publisher · View at Google Scholar
  • Vandanajay Bhatia, Jian-Jun Wen, Michele A. Zacks, and Nisha Jain Gargpp. 1423–1450, 2009. View at Publisher · View at Google Scholar
  • Geert F. Wiegertjes, and Maria Forlenza, “Nitrosative stress during infection-induced inflammation in fish: Lessons from a host-parasite infection model,” Current Pharmaceutical Design, vol. 16, no. 38, pp. 4194–4202, 2010. View at Publisher · View at Google Scholar
  • Israel Quijano-Hernandez, and Eric Dumonteil, “Advances and challenges toward a vaccine against Chagas disease,” Human Vaccines, vol. 7, no. 11, pp. 1184–1191, 2011. View at Publisher · View at Google Scholar
  • Bruno Manta, Marcelo Comini, Andrea Medeiros, Martín Hugo, Madia Trujillo, and Rafael Radi, “Trypanothione: A unique bis-glutathionyl derivative in trypanosomatids,” Biochimica et Biophysica Acta (BBA) - General Subjects, vol. 1830, no. 5, pp. 3199–3216, 2013. View at Publisher · View at Google Scholar
  • Alexandre Morrot, “The Role of Sialic Acid-Binding Receptors (Siglecs) in the Immunomodulatory Effects of Trypanosoma cruzi Sialoglycoproteins on the Protective Immunity of the Host,” Scientifica, vol. 2013, pp. 1–7, 2013. View at Publisher · View at Google Scholar
  • S. I. Cazorla, M. N. Matos, N. Cerny, C. Ramirez, A. S. Alberti, A. E. Bivona, C. Morales, C. A. Guzman, and E. L. Malchiodi, “Oral Multicomponent DNA Vaccine Delivered by Attenuated Salmonella Elicited Immunoprotection Against American Trypanosomiasis,” Journal of Infectious Diseases, 2014. View at Publisher · View at Google Scholar
  • Daniela V. Andrade, Kenneth J. Gollob, and Walderez O. Dutra, “Acute Chagas Disease: New Global Challenges for an Old Neglected Disease,” Plos Neglected Tropical Diseases, vol. 8, no. 7, 2014. View at Publisher · View at Google Scholar
  • Héctor J. Finol, and Antonio Roschman-González, “Ultrastructural Study on Tissue Alterations Caused by Trypanosomatids in Experimental Murine Infections,” Frontiers in Public Health, vol. 2, 2014. View at Publisher · View at Google Scholar
  • Yenny Alviarez, Maria Lares, Mercedes Viettri, Cruz M. Aguilar, Leidi Herrera, and Elizabeth Ferrer, “Standardization of a direct agglutination test for the immunodiagnosis of Chagas disease,” Biomedica, vol. 34, no. 2, pp. 308–317, 2014. View at Publisher · View at Google Scholar
  • M.H. Vicco, F. Ferini, L. Rodeles, M. Baretta, I. Marcipar, and O.A. Bottasso, “Non-uremic calciphylaxis and Chagas disease,” Revista Clínica Española, 2014. View at Publisher · View at Google Scholar
  • Catherine J. Perez, Alan J. Lymbery, and R.C. Andrew Thompson, “Reactivation of Chagas Disease: Implications for Global Health,” Trends in Parasitology, 2015. View at Publisher · View at Google Scholar
  • Ana Flávia Nardy, Célio Geraldo Freire-de-Lima, and Alexandre Morrot, “ Immune Evasion Strategies of Trypanosoma cruzi ,” Journal of Immunology Research, vol. 2015, pp. 1–7, 2015. View at Publisher · View at Google Scholar
  • Alexandre Morrot, Silvina R. Villar, Florencia B. González, and Ana R. Pérez, “Evasion and Immuno-Endocrine Regulation in Parasite Infection: Two Sides of the Same Coin in Chagas Disease?,” Frontiers in Microbiology, vol. 7, 2016. View at Publisher · View at Google Scholar
  • Alexandre Morrot, Silvina R. Villar, Florencia B. Gonzalez, and Ana R. Perez, “Evasion and Immuno-Endocrine Regulation in Parasite Infection: Two Sides of the Same Coin in Chagas Disease?,” Frontiers In Microbiology, vol. 7, 2016. View at Publisher · View at Google Scholar
  • Sarah M. Gunter, Kathryn M. Jones, Bin Zhan, Heather T. Essigmann, Kristy O. Murray, Melissa N. Garcia, Rodion Gorchakov, Maria Elena Bottazzi, Peter J. Hotez, and Eric L. Brown, “Identification and Characterization of the Trypanosorna cruzi B-cell Superantigen Tc24,” American Journal Of Tropical Medicine And Hygiene, vol. 94, no. 1, pp. 114–121, 2016. View at Publisher · View at Google Scholar
  • Sarah M. Gunter, Kathryn M. Jones, Christopher A. Seid, Heather T. Essigmann, Bin Zhan, Ulrich Strych, Maria Elena Bottazzi, Peter J. Hotez, and Eric L. Brown, “ Mutations to Cysteine Residues in the Trypanosoma cruzi B-Cell Superantigen Tc24 Diminish Susceptibility to IgM-Mediated Hydrolysis ,” Journal of Parasitology, vol. 103, no. 5, pp. 579–583, 2017. View at Publisher · View at Google Scholar
  • Bruno Manta, Mariana Bonilla, Lucía Fiestas, Mattia Sturlese, Gustavo Salinas, Massimo Bellanda, and Marcelo A. Comini, “Polyamine-based thiols in Trypanosomatids: evolution, protein structural adaptations and biological functions,” Antioxidants & Redox Signaling, 2017. View at Publisher · View at Google Scholar
  • David H. Truong, Marcus M. Riedhammer, and Kathya Zinszer, “Non-uraemic calciphylaxis successfully treated with pamidronate infusion,” International Wound Journal, 2018. View at Publisher · View at Google Scholar